From First Principles

Weekly breakdown of science news covering physics, space, AI and biotech AI summary

Krishna Choudhary and Lester Nare Visit website › Science · EN · 67 episodes · latest 2026-11-11

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What it is about

From First Principles is a fast, funny, and rigorous breakdown of the biggest science stories of the week, hosted by Lester Nare and physicist Krishna Choudhary, PhD. We go past headlines into the actual mechanics: what happened, why it matters, and what everyone’s missing. Expect physics, space, AI, energy, biotech, and the occasional “wait… is that real?” story. If you’re curious, skeptical, and you like learning in public — you’re in the right place.

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Krishna Choudhary and Lester Nare

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Latest episodes

Mapping Humanity From Space: NASA’s Black Marble with Dr. Miguel Román

2026-11-11 · 48 min · Season 2, episode 67

How can a weather satellite see Ramadan, Christmas and a blackout? Dr. Miguel Román joins Krishna Choudhary to explain NASA's Black Marble: nightly maps of the lights on Earth, from a single band on the VIIRS…
Destroying Tumors With Sound: Histotripsy with Dr. Zhen Xu

2026-11-05 · 1 hr 5 min · Season 2, episode 66

Can sound destroy a tumor without an incision? Dr. Zhen Xu joins Krishna Choudhary to explain histotripsy: focused ultrasound that creates tiny bubbles to mechanically break apart tissue, without relying on heat. From a…
What Happens When AI Gets a Lab?

2026-10-21 · 1 hr 39 min · Season 2, episode 65

What happens when AI moves beyond the chatbot and into the laboratory? From Claude-designed proteins that bind scorpion toxins to robots that assemble optics experiments, we examine what AI can do for science and what…
Nobel Prize 2026: The Science Gets Stranger

2026-10-16 · 1 hr 59 min · Season 1, episode 64

Can light restore aspects of sight? Can recalling a cold experience change an animal's metabolism? And what can ghost particles and mirror-image molecules tell us about the universe? Lester Nare and Krishna Choudhary…
Nobel Prize in Chemistry 2026 Explained: Mirror Molecules (EP 63)

2026-10-07 · 1 hr 21 min · Season 1, episode 63

Why does life favor one molecular mirror image? The 2026 Nobel Prize in Chemistry honors Henri B. Kagan and Kenso Soai for nonlinear effects and autocatalysis in asymmetric organic synthesis. Lester Nare and Krishna…
Nobel Prize in Physics 2026 Explained: IceCube & Neutrinos (EP 62)

2026-10-06 · 1 hr 2 min · Season 1, episode 62

Why build a telescope inside a billion tons of Antarctic ice? The 2026 Nobel Prize in Physics recognizes Francis Halzen's work on IceCube and the discovery of high-energy neutrinos from the cosmos. In Episode 62 of From…
Nobel Prize in Medicine 2026 Explained: Optogenetics (EP 61)

2026-10-05 · 1 hr 11 min · Season 1, episode 61

How do you prove what a brain cell actually does? The 2026 Nobel Prize in Medicine celebrates a remarkable answer: give cells a light-sensitive protein, then switch their activity on or off with light. In Episode 61 of…
2026 Nobel Prize Predictions: Medicine, Physics & Chemistry (EP 60)

2026-10-03 · 41 min · Season 1, episode 60

Who could win the 2026 Nobel Prizes? From the science behind Ozempic to quantum interference and droplets inside living cells, Lester Nare and Krishna Choudhary make their picks for Medicine, Physics and Chemistry, and…
Golden Goose Awards 2026: The Science Behind the Winners (Part 1) (EP 59)

2026-09-29 · 2 hr 7 min · Season 1, episode 59

What connects a noise complaint, holiday lights seen from space, and the physics of a coffee stain? Three unexpected paths from basic research to discoveries with real-world impact. Krishna Choudhary and Lester Nare…
What OpenAI Actually Did to Navier-Stokes (EP 58)

2026-09-24 · 4 hr 9 min · Season 1, episode 58

What does it mean to solve an equation that describes almost every fluid around us, from the air over a wing to the water swirling down a drain? In Episode 58 of From First Principles, Lester Nare and Krishna Choudhary…

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Publisher details

Oldest episode in feed: 08/2025 · over a year
Typical length: 1 hr 34 min
Format: Episodic Newest first, episodes stand alone

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