No Priors: Artificial Intelligence | Technology | Startups

Conversations with AI researchers and founders on the path to AGI AI summary

Conviction Technology · EN · 188 episodes · latest 2026-11-12

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What it is about

At this moment of inflection in technology, co-hosts Elad Gil and Sarah Guo talk to the world's leading AI engineers, researchers and founders about the biggest questions: How far away is AGI? What markets are at risk for disruption? How will commerce, culture, and society change? What’s happening in state-of-the-art in research? “No Priors” is your guide to the AI revolution. Email feedback to show@no-priors.com. Sarah Guo is a startup investor and the founder of Conviction, an investment firm purpose-built to serve intelligent software, or "Software 3.0" companies. She spent nearly a decade incubating and investing at venture firm Greylock Partners. Elad Gil is a serial entrepreneur and a startup investor. He was co-founder of Color Health, Mixer Labs (which was acquired by Twitter). He has invested in over 40 companies now worth $1B or more each, and is also author of the High Growth Handbook.

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Latest episodes

Powering AI-Driven Drug Discovery with President of Isomorphic Labs Max Jaderberg

2026-11-12 · 39 min · Season 1, episode 159

Drug discovery and development has long relied on expensive, time-consuming empirical trial and error. By shifting the discovery process onto computers, Isomorphic Labs wants to fundamentally change medicine from a…
Tokenization, Agentic Trading, Harmonic: Robinhood's Mission to Expand Ownership with CEO Vlad Tenev

2026-11-05 · 54 min · Season 1, episode 186

What does it mean to build wealth as an individual investor in today’s society, especially as gains continue to get concentrated into smaller groups of VCs or institutional investors? Robinhood’s CEO and co-founder Vlad…
Taking on ServiceNow: Coding Agents the Rest of Us with Serval Co-Founder and CEO Jake Stauch

2026-10-29 · 38 min

What happens when you put code-generation agents in the hands of enterprise IT teams? With Serval, you get a system where it's easy for everyone to be a builder. Sarah Guo and Elad Gil sit down with Serval co-founder…
Democratizing Security for the Agentic Web with Cloudflare CTO Dane Knecht

2026-10-23 · 41 min · Season 1, episode 184

In the transition to the agentic web, security has become an afterthought. Now, organizations are racing to figure out what AI security means, and how to keep their data safe. Live from Cloudflare Connect, Sarah Guo…
The New Apex Predator: CrowdStrike CEO George Kurtz on Adversaries Armed With AI Agents

2026-10-22 · 45 min

Adversaries are already running AI agents, and the fastest attacks now play out in seconds. Sarah Guo and Elad Gil sit down with CrowdStrike president and CEO George Kurtz on what AI-equipped attackers mean for…
The Changing Physics of Cybersecurity and Drug Development with OpenAI President Greg Brockman

2026-10-15 · 39 min · Season 1, episode 129

Technology has always been the fundamental driver of improvement for human quality of life. And with the recent rollout of advanced frontier models, like OpenAI’s GPT-6, humanity can now massively accelerate scientific…
Beam: The Great American Open Model with ReflectionAI Co-Founder and CEO Misha Laskin

2026-10-09 · 1 hr 10 min · Season 1, episode 181

Is the future of frontier AI open or closed? ReflectionAI co-founder and CEO Misha Laskin joins Sarah Guo and Elad Gil to discuss the launch of Beam, the company’s 500 billion parameter open-weight reasoning model.…
Frontier Chips for Frontier AI Labs, with Walter Goodwin, Founder/CEO of Fractile

2026-10-02 · 36 min

Founder and CEO of full-stack AI chip company Fractile, Walter Goodwin, joins Sarah Guo to discuss the bets he’s made on the future of the chip market as other major players like Broadcom, NVIDIA, and AMD try to…
Re-Founding Incumbents for the AI Era with Sequence Holdings Co-Founder and CEO Michael Lee

2026-09-24 · 43 min

Can AI transform legacy incumbents rather than replacing them? Sequence Holdings co-founder and CEO Michael Lee joins Sarah Guo to discuss how holding company structures and engineering integrations are reshaping market…
Why Diffusion Will Win AI Inference with Inception Co-Founder and CEO Stefano Ermon

2026-09-18 · 38 min · Season 1, episode 178

As generative AI hits hardware and latency bottlenecks, Stanford professor, diffusion pioneer, and Inception co-founder and CEO Stefano Ermon is betting on a radical new architecture. Stefano joins Sarah Guo to talk…

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Publisher details

Oldest episode in feed: 02/2023 · over 3 years
Typical length: 39 min
Format: Episodic Newest first, episodes stand alone

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