Talk Python To Me

Weekly interviews with Python developers on packages, tools and projects AI summary

Michael Kennedy Visit website › Technology · EN · 567 episodes · latest 2026-11-03

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What it is about

Talk Python to Me is a weekly podcast for Python developers, data scientists, and AI builders, hosted by developer and entrepreneur Michael Kennedy. We dive deep into the packages, tools, and people shaping Python, from web development and data science to AI and LLMs. If you're new to Python, you'll quickly learn the ins and outs of the community by hearing from its leaders. And if you've been Pythoning for years, you'll hear about your favorite packages and the hot new ones coming out of open source.

Publisher’s own description, taken unchanged from the podcast feed.
Copyright 2015-2026

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Latest episodes

#568: Cloudflare Python Workers

2026-11-03 · 1 hr 2 min · Episode 568

Where does your Python code actually run? A server in Virginia? A container in Frankfurt? Pyodide put Python into the browser. Cloudflare put the browser into the server. Combine the two and you get Python Workers, now…
#567: Personal AI Agents for Pythonistas

2026-10-27 · 1 hr 7 min · Episode 567

The most popular Python project you've probably never heard of has 252,000 GitHub stars and merged over 1,800 pull requests in a single week. It's Hermes, a self-hosted AI agent you program just by talking to it. And it…
#566: State of the art in Python 2026

2026-10-17 · 1 hr 5 min · Episode 566

Which of your Python tools would you still pick if you started fresh today? For a long time, the answer was easy. The stack felt settled. AI has reopened almost every one of those choices. Some tools got faster. Others…
#565: Tachyon, Python 3.15's Built-in Sampling Profiler

2026-10-02 · 1 hr 28 min · Episode 565

Do you know what's actually slow in your Python app? Or are you guessing? Until now, profiling Python meant a tracing profiler that made your code 2 to 3 times slower. Or a third-party tool that broke with every new…
#564: EVE Online Departs for Python 3

2026-09-22 · 1 hr 8 min · Episode 564

Every ship in EVE Online eventually undocks and leaves the station. This time, it's the whole game. EVE has run on Python 2 since it launched in 2003, all 2.4 million lines of it, on a custom Stackless interpreter that…
#563: Getting Started with Rust as Python Devs

2026-09-16 · 1 hr 11 min · Episode 563

Lint the entire CPython code base from scratch. It takes 0.3 seconds. Three blinks of an eye. That is ruff, and it is written in Rust. So are Pydantic, Polars, uv, and Granian. Rust shows up in Python three ways: tools…
#562: DuckLake: The Lakehouse That's Just SQL and Parquet

2026-09-10 · 1 hr 11 min · Episode 562

How many files does your query read before it reads any data? On some data lakes, you go through JSON and metadata files first, just to learn which Parquet files matter. DuckLake asks one SQL question instead. The…
#561: TonIO, a Multi-threaded Async Runtime for Python

2026-09-04 · 1 hr 16 min · Episode 561

How many cores does your machine have, 10, 18? Your async Python code uses just one of them. That isn't a bug in asyncio. That's the design, and optimizing event loops to be faster by 20% doesn't change it. So Giovanni…
#560: Building a Research OS: From Django to 30,000 Samples

2026-08-26 · 1 hr 3 min · Episode 560

In 2020, a gastroenterologist in Glasgow did the math on his new research study and came up with 30,000 samples, arriving over two years from three cities and a dozen hospitals. He asked around about how researchers…
#559: 12 Things You Should (and Shouldn't) Do in AWS

2026-08-19 · 1 hr 8 min · Episode 559

Your site is down. It's 3am. Is it a bug, a bill, or a breach? You can't tell yet, and everyone is watching you find out. Matt Lea has spent fifteen years being the person companies call when an outage is costing them…

Episode details from the publisher’s feed. Playback happens at the publisher.

Publisher details

Oldest episode in feed: 03/2015 · over 11 years
Typical length: 1 hr 2 min
Format: Episodic Newest first, episodes stand alone

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